Shadoo/PrP (Sprn0/0/Prnp0/0) double knockout mice
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چکیده
منابع مشابه
Lingual deficits in neurotrophin double knockout mice.
Brain-derived neurotrophic factor (BDNF) and Neurotrophin 3 (NT-3) are members of the neurotrophin family and are expressed in the developing and adult tongue papillae. BDNF null-mutated mice exhibit specific impairments related to innervation and development of the gustatory system while NT-3 null mice have deficits in their lingual somatosensory innervation. To further evaluate the functional...
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*Center for Basic Neuroscience, Departments of Molecular Genetics, §Psychiatry, and ¶Biochemistry, and **Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390; †Department of Human Morphology and Applied Biology, University of Pisa and Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Neurologico Mediterraneo Neuromed, 86077 Pozzilli, Ita...
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PURPOSE To determine the roles of intercellular communication in embryonic eye growth and development, mice with a targeted deletion of the Cx43 gene were examined, and mice without both Cx43 and Cx50 were generated and analyzed. METHODS Embryonic eyes and lenses from wild-type mice, or mice deficient in Cx43, Cx50, or both Cx43 and Cx50 were collected and analyzed structurally by light and e...
متن کاملShadoo/PrP (Sprn0/0/Prnp0/0) double knockout mice
Shadoo (Sho) is a brain glycoprotein with similarities to the unstructured region of PrP (C) . Frameshift alleles of the Sho gene, Sprn, are reported in variant Creutzfeldt-Jakob disease (vCJD) patients while Sprn mRNA knockdown in PrP-null (Prnp(0/0) ) embryos produces lethality, advancing Sho as the hypothetical PrP-like "pi" protein. Also, Sho levels are reduced as misfolded PrP accumulates ...
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ژورنال
عنوان ژورنال: Prion
سال: 2012
ISSN: 1933-6896,1933-690X
DOI: 10.4161/pri.21867